- S1dewards - Experimental artwork and narrative style. Offers a variety of styles and presentations.
- SageBrush - SageBrush comics, all about the life of a sagebrush, caught in a comic strip.
- Salamander Bits - Unique daily cartoon that mixes a new face with a different quote each day. Many of these ideas and portraits are developed during artist T. wEieR's frequent trips on public transportation.
- Sallad's Toonpage - History, making cartoons, links, extras, and contacts.
- Sally Forth - Popular U.S. strip about a working mother and her family. About the strip, the cartoonist, and the characters, with archives of past daily strips.
- Scary Devil - A adventures of a stick figure devil. Contains some adult content. By Angy and Keith.
- Schlock Mercenary - Travel the galaxy. Meet new and fascinating life-forms.
- Schoolbooks and Brimstone - Topical comic on "heaven, hell and high school." By Stephanie D. Lostimolo.
- Scott Tirades, The - A humorous look at a teenager's life.
- Scott's Mind - Cartoons like a car crash. You know it's going to be twisted, but you stop and look, anyway.
- Scrambled Pancakes - A philosopher, a simpleton, a businessman, a humanist, and a mad scientist attempt to make the world a better place and occasionally drive each other crazy in the process.
- Scrubs - Detailing the life and times of two best friends. Includes an archive and character profiles.
- Second Nature - From UVA's Cavalier Daily, Second Nature is a comic strip about Cameron's resistance to growing up. Includes an archive and character profiles.
- Shallow Grave Comics - A collection of absurd and hilarious comic strips updated weekly. Created by Sean Polyn, currently based in Charlottesville, Virginia.
- Sharkey, Dog - Irish cartoonist. Features titles such as My Days as a Wage Slave, Phoenix Gags, Bollox Man, and Temple Bar Tosser.
- Sheldon - Cartoon following the adventures of a ten-year old genius, his talking duck, and their billion-dollar web company. Created by Dave Kellett.
- Sherman's Lagoon - Sherman's Lagoon is a syndicated daily comic strip by Jim Toomy about a dimwitted great white shark named Sherman and his sea turtle sidekick named Fillmore. Updated daily, plus archives, computer stuff to download and books to buy.
- Shoe - Official site with daily comics, games, a fan forum, a history of the strip, and character biographies.
- Sidewalk Bubblegum - Political and social commentary from the pen of Clay Butler. Syndicated comic strip covers issues such as war, gender, capitalism, race and environment.
- Silent Comics - Humorous comics without any words. Created by Motoi Motoni from Japan.
- SinFest - Strip dealing with contemporary issues and religion. Created by Tatsuya Ishida.
- Skinny Panda - Comic strip about a Panda by Phil Cho.
- Slap The Comic - Features a geek outlook on life and an addiction to the Internet. Offers an archive.
- Slow Wave - Jesse Reklaw draws a collective dream-diary comic strip, authored by readers from around the world.
- Slylock Fox and Comics for Kids - Fun, award winning website featuring cartoon mystery puzzles, drawing lessons, contest, archive of educational and entertaining comic strips updated daily.
- Small World - Starring "Tad", a philosopher, consumer and victim of modern life. New strips every Friday. Free e-mail subscriptions.
- smallgreY - Finally, the comic strip to fill your void! With a smallgreY alien, a sexy Venutian, a tormented Martian, 3 cats, the Lorang and a 'primitive' man!
- Smapdi - An online comic about a bunch of friends trying their best not to kill each other.
- Snake Tales (Net Snake) - The Official site of "Snake Tales" and "Lennie the Loser" comic strips, by Australian cartoonist, Sols. You can check out Snake's girlfriend, talk to The Great Spirit, see information about the artist and lots of other goodies!!
- Snapshots - Free daily panel cartoon by Jason Love. With an archive and some extra goodies.
- Sneaky and Creepy - A cartoon about two roaches. Also offers a short introduction to an animation project, ecards and character sketches.
- Snorty and Co. - The cartoon adventures of an English mini-car.
- Soap On A Rope - Daily comic strip by Bob Roberds with a complete archive.
- Soda Venture - A computer graphic comic by Jacob Gray - includes an archive and character profiles
- Soft Targets Inc. - Daily comics by James Koput featuring Fester the Rat, Garth the Pig and Scud the Vulture. With archives, background information and the Watt E-zine.
- Somedaze - Cartoons of eccentric thought and weird scribblings updated daily. Somedaze has appeared in newspaper and magazines all over the place. Read it for a daily laugh in contemporary humor.
- Space Kadette - The life of Tommy Kadette as he is forced to leave Earth when his dad gets a job on Mars. Written by M. W. Martin and illustrated by Brian Mansfield.
- Space Moose - Offensive comic strip about the extremely vulgar Space Moose. Includes extensive archives.
- SpamFish - A loony and toony cartoon that likes to use slapstick comedy and witty phrases. Starring SpamFish, an orange cat.
- Spanky the Monkey - Spanky is an online comic strip about a primate lost in a world gone bananas.
- Spaz Labs - Weekly comic strip about research scientists, talking hamsters, mutants and robots. Oh my. By C. G. Muggridge.
- Spencer Green - Full run of this college cartoon by Peter Zale.
- Spooner - Internationally syndicated comic strip featuring Spooner and Roxanne discovering life after marriage. By Ted Dawson.
- Sport Monkeys - Sport monkey competition!
- Spudmuffins - Features an archive of the strips by T. Vince Barbarie.
- Spungifeel Comics and Somedaze Cartoons - The eccentric daily cartoons Somedaze and Salamander Bits.
- Squinkers - Comic strip about life at a country bed and breakfast.
- Stand Easy - STAND EASY, the military cartoon by Ben Crothers, is now on the web! Strips, archive, how-to's. STAND EASY also appears in the Australian Army newspaper.
- Steverino - Steverino and his friends go about their daily lives. Includes archive, artist information and character profiles.
- Stick Dude - This Site contains many comics of the adventures of a stick figure called Stick Dude. Stick Dude has a photo album, oponions, and silly adventures, as well as some cooky friends.
- Stickman - The adventures of a talking stick figure.
- Stink Child - Offensive comics drawn in a minimalist amateur style. Plenty of adult language, and juvenile histrionics intended to offend.
- Storm Corps - Features the cast, a gallery, an about page and contact information.
- Story Minute - Minute stories by Carol Lay, on Salon.com.
- Strange Breed - Wacky, off the wall single panel cartoons.
- Strange Candy - Manga-style funny strip. By Okashina Okashi.
- Stripped Again - A humorous comic strip about the lives of some college students and friends, struggling to survive, including with the opposite sex. By Morten B. Helland.
- Suburban Jungle - The life, loves, and career of aspiring supermodel and ferocious predator, Tiffany Tiger. By John "the Gneech" Robey.
- Sucktales - Meet the superhero Silver Snaker, the aggressive skating professional Dark Rider or the little French boy Petit Jacques. Our Online-Comic is updated every Sunday. Special Feature: have a look at some scanned images from our schoolbooks.
- Sun Puppy - Welcome to Brittany Hollow! Where you can meet a couple of sun loving puppies, a thoughtful computer, a big dog or two and a host of other companions.
- Super Puppies From Outer Space - An ongoing comic strip adventure that is suitable for all.
- Superosity - Daily Comic Strip in color by Chris Crosby.
- Surf Rat & Spencer - A classic-style comic strip about friendship, dating and everyday life, featuring Surf Rat & Spencer. Updated daily in color.
- SWAMI - A new flavor of humor from India. By Ashok Dongre.
- The Scott Tirades - A teenager's gripes about the unfairness of life. Includes past comics and information about the artist.
- The SporkMan Chronicles - Full-color adventures of SporkMan, the superhero that says Feh to superpowers.
- The Styx - AD&D? Are you in or out?
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